A Grand Challenge for Computing: Towards Full Reactive Modeling of a Multi-cellular Animal

نویسنده

  • David Harel
چکیده

Biological systems can be modeled beneficially as reactive systems, using languages and tools developed for the construction of man-made systems. Our long-term aim is to model a full multicellular animal as a reactive system ---specifically, the C. elegans nematode worm, which is complex, but very well-defined in terms of anatomy and genetics. The challenge is to construct a full, true-to-all-known-facts, 4-dimensional, fully animated model of the development and behavior of this worm (or of a comparable multi-cellular animal), which is easily extendable as new biological facts are discovered.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A Grand Challenge: Full Reactive Modeling of a Multi-cellular Animal

One of the central issues in software and system engineering over the last couple of decades has been to develop languages, methods and tools for the reliable construction reactive systems. The term, coined in 1985, denotes systems whose complexity stems not necessarily from complicated computation but from complicated reactivity over time. Such systems are most often highly concurrent and time...

متن کامل

On the Full Organism Challenge: Or, Can we Computerize an Elephant?

We show how techniques from computer science and software engineering can be applied beneficially to research in the life sciences. I will discuss the idea of comprehensive and realistic modeling of biological systems, where we try to understand and analyze an entire system in detail, utilizing in the modeling effort all that is known about it. I will address the motivation for such modeling an...

متن کامل

A Novel Design of a Multi-layer 2:4 Decoder using Quantum- Dot Cellular Automata

The quantum-dot cellular automata (QCA) is considered as an alternative tocomplementary metal oxide semiconductor (CMOS) technology based on physicalphenomena like Coulomb interaction to overcome the physical limitations of thistechnology. The decoder is one of the important components in digital circuits, whichcan be used in more comprehensive circuits such as full adde...

متن کامل

Integrated modeling and solving the resource allocation problem and task scheduling in the cloud computing environment

Cloud computing is considered to be a new service provider technology for users and businesses. However, the cloud environment is facing a number of challenges. Resource allocation in a way that is optimum for users and cloud providers is difficult because of lack of data sharing between them. On the other hand, job scheduling is a basic issue and at the same time a big challenge in reaching hi...

متن کامل

Probabilistic Multi Objective Optimal Reactive Power Dispatch Considering Load Uncertainties Using Monte Carlo Simulations

Optimal Reactive Power Dispatch (ORPD) is a multi-variable problem with nonlinear constraints and continuous/discrete decision variables. Due to the stochastic behavior of loads, the ORPD requires a probabilistic mathematical model. In this paper, Monte Carlo Simulation (MCS) is used for modeling of load uncertainties in the ORPD problem. The problem is formulated as a nonlinear constrained mul...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2003